Hexb enzyme deficiency leads to lysosomal abnormalities in radial glia and microglia in zebrafish brain development
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چکیده
منابع مشابه
Early oleate deficiency leads to severe defects in fetal rat liver development
Objective(s): Oleate can be produced through de novo synthesis, which contributes to biological processes and signaling pathways. However, the role of this non-essential fatty acid in hepatic development remains unclear. The current study aimed to evaluate the influence of early oleate deficiency induced by the inhibitor of de novo oleate synthesis MF-438 on fetal rat ...
متن کاملRadial Glia and Neurogenesis in the Embryonic Zebrafish Hindbrain
This thesis is an investigation of the behaviour of radial progenitors in the hindbrain of the teleost fish Danio rerio, the zebrafish, during embryonic neurogenesis. These progenitors have many of the characteristics of radial glial cells described in other systems. Recent studies from several laboratories worldwide have shown that radial glia play an important role in the patterning and neuro...
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GRETCHEN BAIN, ISAAC ENGEL, ELS C. ROBANUS MAANDAG, HEIN P. J. TE RIELE, JOSEPH R. VOLAND, LESLIE L. SHARP, JEROLD CHUN, BING HUEY, DAN PINKEL, AND CORNELIS MURRE* Department of Biology and Department of Pharmacology, University of California, San Diego, La Jolla, California 92093; Department of Molecular Genetics, The Netherlands Cancer Institute, 1060 CX Amsterdam, The Netherlands; and Cancer...
متن کاملRibosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family.
Mutations in several ribosomal proteins (RPs) lead to Diamond-Blackfan anemia (DBA), a syndrome characterized by defective erythropoiesis, congenital anomalies, and increased frequency of cancer. RPS19 is the most frequently mutated RP in DBA. RPS19 deficiency impairs ribosomal biogenesis, but how this leads to DBA or cancer remains unknown. We have found that rps19 deficiency in ze-brafish res...
متن کاملLysosomal enzyme abnormalities in preleukaemic Sweet's disease: case report.
Quantitative and qualitative abnormalities in marrow lysosomal enzymes, suggestive of acute myeloid leukaemia, were detected in a patient with Sweet's disease and monocytosis 12 months before she presented with acute myelomonocytic leukaemia. Biochemical characterisation of blood and marrow cell extracts may help to identify those patients with Sweet's disease and other preleukaemic conditions ...
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ژورنال
عنوان ژورنال: Glia
سال: 2019
ISSN: 0894-1491,1098-1136
DOI: 10.1002/glia.23641